Stacy Renee Lester was last seen on August 9, 2009, after having a medical procedure at Tuomey Regional Medical Center in Sumter, South Carolina. She called her mother to come and get her, but her sister went instead and she was not there. She has never been heard from again.

Her case was mistakenly closed by law enforcement, who thought she had returned home, but was reopened when they found out she hadn't. Her case remains unsolved.