Ira Briscoe was last seen in West Plains, Missouri on December 17, 2020. He has not been heard from since. His family reported him missing on December 23. A week after the missing persons report was filed, his car, a 1995 Mercury Sable, was found at a scrapyard.

Authorities are looking into the possibility that his disappearance is connected to a shooting that occurred the day before he went missing, in which two people known to him exchanged gunfire inside a residence in Koshkonong, Missouri. Briscoe's roommate, Limon Little, also went missing under suspicious circumstances two days before Briscoe. It is not clear if the two cases are connected, but both remain unsolved.